Some aspects of red cell production and destruction
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Some aspects of red cell production and destruction

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Published in New York .
Written in English


  • Blood cells.

Book details:

Edition Notes

Statementby Eric Ponder [and others]
SeriesAnnals of the New York Academy of Sciences,, v. 48, art. 7
ContributionsPonder, Eric, 1898-, Conference on Red Cell Production and Destruction (1946 : New York)
LC ClassificationsQ11 .N5 vol. 48
The Physical Object
Pagination577-703 p.
Number of Pages703
ID Numbers
Open LibraryOL263574M
LC Control Numbermed47001965

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The red cell destruction is primarily due to the complement fixation and happens within the blood vessels (intravascular hemolysis) (Figure ). The IgM autoantibodies at low temperature activate the complement cascade and bind the erythrocyte membrane, causing small holes in the red cell membrane and consequently hemolysis [, ]. ***Cell mediated immunity: production of activated T lymphocytes (T cells), which directly attack unwanted cells. Origins of B and T cells Both B and T lymphocytes, like all blood cells, are derived from a common stem cell in bone marrow. Jul 28,  · Red blood cells are derived from stem cells in red bone marrow. New red blood cell production, also called erythropoiesis, is triggered by low levels of oxygen in the blood. Low oxygen levels can occur for various reasons including blood loss, presence in high altitude, exercise, bone marrow damage, and low hemoglobin levels. Dec 26,  · A number of tests have been developed to measure the three main components of red cell kinetics: the red cell mass, the rate of red cell production, and the rate of red cell destruction. Some of these are simple but indirect, such as the hematocrit, reticulocyte count, haptoglobin, lactic dehydrogenase and unconjugated bilirubin concentration.

Anemia can be caused by blood loss, decreased red blood cell production, and increased red blood cell breakdown. Causes of blood loss include trauma and gastrointestinal bleeding. Causes of decreased production include iron deficiency, vitamin B12 deficiency, thalassemia, and a number of neoplasms of the bone cyrusofficial.comciation: /əˈniːmiə/. Castle, William B. (William Bosworth), Castle, William B. (). Castle, William Bosworth William Bosworth Castle William Bosworth Castle American physician. Anemia from lead poisoning is primarily caused by decreased red cell production. Red cell destruction (hemolysis) contributes to anemia (Beutler, ). With improved awareness and preventive measures to eliminate the danger of lead poisoning, its incidence has fallen significantly in the US in the past 30 years. Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen).It has numerous possible consequences, ranging from relatively harmless to life-threatening. The general classification of hemolytic anemia is either inherited or Specialty: Hematology.

Anemia is defined as a decrease in the red blood cell mass. Accurate measurements require labeling of erythrocytes followed by in vivo quantification of the dilution of the labeled cells in the circulation. Obviously, this is an impractical method for the detection of anemia, and measurements of either the hemoglobin concentration, the hematocrit, or red blood cell count are used. Each of. Many substances are recycled through the blood; for example, iron released during the destruction of old red cells is conveyed by the plasma to sites of new red cell production where it is reused. Each of the numerous components of the blood is kept within appropriate concentration limits by an effective regulatory mechanism. Apr 30,  · The anemia of chronic illness produces a red cell with a decreased life span. In addition, the bone marrow does not respond by increasing red cell production. INTRODUCTION. Evaluation for anemia is one of the most common problems seen in clinical practice. While the evaluation may be straightforward in an otherwise healthy individual with a single cause of anemia, in many cases the cause is not readily apparent and multiple conditions may be contributing.